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Pharmacological evaluation of a novel skeleton compound isobavachin (4′,7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity

Zean Zhao, Jian Luo, Hui Liao, Fengxin Zheng, Xinhua Chen, Jiajun Luo, Yongjun Chen, Kunlu Zhao, Shuqin Zhang, Jinhong Tian, Ting Wu, Yongmei Li, Lu Li, Yang Yang, Cuiting Lin, Qun Zhang, Yuanxin Tian, Jianxin Pang, Yuanxin Tian, Jianxin Pang

2023Bioorganic Chemistry29 citationsDOI

Topics & Concepts

ChemistryXanthine oxidaseIC50In vivoUric acidPharmacologyDocking (animal)BiochemistryHyperuricemiaProbenecidIn vitroStereochemistryEnzymeBiologyNursingBiotechnologyMedicineGout, Hyperuricemia, Uric AcidToxin Mechanisms and ImmunotoxinsNatural product bioactivities and synthesis
Pharmacological evaluation of a novel skeleton compound isobavachin (4′,7-dihydroxy-8-prenylflavanone) as a hypouricemic agent: Dual actions of URAT1/GLUT9 and xanthine oxidase inhibitory activity | Litcius