Litcius/Paper detail

Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity

Changjun Zhang, Yi Lu, Jingqi Zhang, Anjie Zang, Jinhui Ren, Zhiyuan Zheng, Miaoliang Fan, Yuanyuan Xie

2023European Journal of Medicinal Chemistry12 citationsDOI

Topics & Concepts

ChemistryReactive oxygen speciesLipid peroxidationPharmacophoreDeferoxaminePharmacologyProgrammed cell deathDeferiproneApoptosisChelationOxidative stressBiochemistryOrganic chemistryMedicineFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsGlutathione Transferases and Polymorphisms