Novel 3-hydroxypyridin-4(1H)-One derivatives as ferroptosis inhibitors with iron-chelating and reactive oxygen species scavenging activities and therapeutic effect in cisplatin-induced cytotoxicity
Changjun Zhang, Yi Lu, Jingqi Zhang, Anjie Zang, Jinhui Ren, Zhiyuan Zheng, Miaoliang Fan, Yuanyuan Xie
Topics & Concepts
ChemistryReactive oxygen speciesLipid peroxidationPharmacophoreDeferoxaminePharmacologyProgrammed cell deathDeferiproneApoptosisChelationOxidative stressBiochemistryOrganic chemistryMedicineFerroptosis and cancer prognosisDrug Transport and Resistance MechanismsGlutathione Transferases and Polymorphisms