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Iridium(III)-Catalyzed C–H Amidation/Cyclization of <i>NH</i>-Sulfoximines with <i>N</i>-Alkoxyamides: Formation of Thiadiazine 1-Oxides

Hui‐Bei Xu, Jiahui Yang, Xin‐Yue Chai, Yanying Zhu, Lin Dong

2020Organic Letters32 citationsDOI

Abstract

The first example of Ir(III)-catalyzed C–H activation/cyclization with N-alkoxyamides as amidation reagents to simultaneously form functionalized thiadiazine 1-oxide derivatives was developed. This one-pot cascade protocol tolerated diverse functional groups and readily constructed various heterocyclic frameworks in moderate to good yield.

Topics & Concepts

ChemistryYield (engineering)IridiumCatalysisReagentCombinatorial chemistryOxideMedicinal chemistryOrganic chemistryMetallurgyMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques
Iridium(III)-Catalyzed C–H Amidation/Cyclization of <i>NH</i>-Sulfoximines with <i>N</i>-Alkoxyamides: Formation of Thiadiazine 1-Oxides | Litcius