Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells
Bin Jia, Xu Zheng, Mo‐Li Wu, Xiaoting Tian, Xue Song, Yanna Liu, Peinan Li, Jia Liu
Abstract
Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidative damage caused by increased reactive oxygen species (ROS) production. Thus, the present study examined the relationship between oxidative stress and sensitivity to resveratrol in glioblastoma cells.
Topics & Concepts
Reactive oxygen speciesResveratrolGlioblastomaOxidative damageOxidative stressOxidative phosphorylationCancer researchChemistryOxygenCell biologyBiologyBiochemistryOrganic chemistrySirtuins and Resveratrol in MedicineMitochondrial Function and PathologyGenomics, phytochemicals, and oxidative stress