A practical “preTACs-cytoblot” platform accelerates the streamlined development of PROTAC-based protein degraders
Zijian Rao, Kailin Li, Ju-Eun Hong, Danni Chen, Baoli Ding, Jiang Li, Xuxin Qi, Jiawen Hu, Bo Yang, Qiaojun He, Xiaowu Dong, Ji Cao, Cheng‐Liang Zhu
Topics & Concepts
ChemistryLinkerDrug discoveryProtein degradationComputational biologyCombinatorial chemistryConjugateFusion proteinBiochemistryComputer scienceProgramming languageRecombinant DNABiologyMathematicsMathematical analysisGeneProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways