A novel label-free electrochemical immunosensor for the detection of heat shock protein 70 of lung adenocarcinoma cell line following paclitaxel treatment using <scp>l</scp>-cysteine-functionalized Au@MnO<sub>2</sub>/MoO<sub>3</sub> nanocomposites
Yi‐An Chen, Yi-An Chen, Ming‐You Shie, Chia‐Che Ho, Sheng-Wen Ye, I‐Wen Peter Chen, Yu‐Yin Shih, Yufang Shen, Yi‐Wen Chen, Yi‐Wen Chen
Abstract
under optimal conditions. Moreover, the immunosensor was effective in detecting HSP70 at low concentrations in a lung adenocarcinoma cell line following Paclitaxel treatment, indicating its potential for early detection of the HSP70 biomarker in organ-on-a-chip and clinical applications.
Topics & Concepts
Detection limitPaclitaxelBiomarkerOxidizing agentChemistryNanocompositeHsp70Materials scienceNanotechnologyChromatographyHeat shock proteinCancerMedicineGeneInternal medicineOrganic chemistryBiochemistryHeat shock proteins researchthermodynamics and calorimetric analysesFuel Cells and Related Materials