Alleviation effects of <i>Lactobacillus plantarum</i> in colitis aggravated by a high-salt diet depend on intestinal barrier protection, NF-κB pathway regulation, and oxidative stress improvement
Yang Chen, Nian Liu, Fangyi Chen, Mengyuan Liu, Mu Yang, Chao Wang, Lusha Xia, Mingye Peng, Mengzhou Zhou
Abstract
. HGD228 treatment also enhanced the production of butyric acid and acetic acid, suppressed pro-inflammatory cytokines, and strengthened the intestinal mucosal barrier. Therefore, HGD228 enhanced the production of beneficial metabolites by regulating inflammatory cytokines and oxidative stress, preserving the mucosal barrier, and enhancing gut microbiota, and mitigated colitis aggravated by a HSD. These results will aid in clinical trials of probiotics and the development of dietary supplements for colitis, with promising application value.
Topics & Concepts
Lactobacillus plantarumOxidative stressMechanism (biology)ChemistryColitisSalt (chemistry)NF-κBCell biologyMicrobiologySignal transductionBiologyImmunologyBiochemistryBacteriaLactic acidGeneticsPhilosophyEpistemologyPhysical chemistryGut microbiota and healthGastrointestinal motility and disordersHelicobacter pylori-related gastroenterology studies