Gestational low-dose BPA exposure impacts suprachiasmatic nucleus neurogenesis and circadian activity with transgenerational effects
Dinushan Nesan, Kira M. Feighan, Michael C. Antle, Deborah M. Kurrasch
Abstract
neurons in the suprachiasmatic nucleus (SCN), the region that regulates circadian rhythms, of F1 and F3 generations. Mechanistically, BPA increased proliferation of hypothalamic neural progenitors ex vivo and caused precocious neurogenesis in vivo. Co-antagonism of both estrogen and androgen receptors was necessary to block BPA's effects on hypothalamic neural progenitors, illustrating a dual role for these endocrine targets. Together, gestational BPA exposure affects development of circadian centers, with lasting consequences across generations.
Topics & Concepts
Transgenerational epigeneticsCircadian rhythmNeurogenesisSuprachiasmatic nucleusEndocrinologyInternal medicineBiologyPregnancyMedicineNeuroscienceOffspringGeneticsAnesthesia and Neurotoxicity ResearchEffects and risks of endocrine disrupting chemicalsBirth, Development, and Health