Photoactivatable prodrug for simultaneous release of mertansine and CO along with a BODIPY derivative as a luminescent marker in mitochondria: a proof of concept for NIR image-guided cancer therapy
Rajeshwari Tiwari, Prashant S. Shinde, Sreejesh Sreedharan, Anik Kumar Dey, Katherine A. Vallis, Santosh B. Mhaske, Sumit Kumar Pramanik, Amitava Das
Abstract
Simultaneous release of two therapeutic reagents, mertansine and CO through photo-induced cleavage of a mitochondria-specific prodrug with improved drug efficacy.
Topics & Concepts
ProdrugBODIPYCancer cellMitochondrionPhotodynamic therapyProgrammed cell deathChemistryLysosomeOrganelleApoptosisCancer researchCancerCell biologyBiochemistryPharmacologyBiophysicsBiologyFluorescenceOrganic chemistryGeneticsEnzymeQuantum mechanicsPhysicsNanoplatforms for cancer theranosticsHeme Oxygenase-1 and Carbon MonoxideLuminescence and Fluorescent Materials