Allelic variation in class I HLA determines CD8<sup>+</sup> T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2.
Joshua M. Francis, Del Leistritz-Edwards, Augustine Dunn, Christina Tarr, Jesse Lehman, Conor Dempsey, Andrew Hamel, Violeta Rayon, Gang Liu, Yuntong Wang, Marcos Wille, Melissa Durkin, Kane Hadley, Aswathy Sheena, Benjamin P. Roscoe, Mark Ng, Graham N. Rockwell, Margaret Manto, Elizabeth Gienger, Joshua Nickerson, Amir Moarefi, Amir Moarefi, Michael S. Noble, T. Malia, Philip D. Bardwell, William Gordon, Joanna F. Swain, Mojca Škoberne, Karsten Sauer, Tim Harris, Ananda W. Goldrath, Alex K. Shalek, Anthony J. Coyle, Christophe Benoıst
Abstract
T cell repertoire shape and utilization of immune recall upon SARS-CoV-2 infection.
Topics & Concepts
BiologyHuman leukocyte antigenCD8Memory T cellEpitopeImmunologyCytotoxic T cellAntigenT cellRepertoireImmune systemGenotypeT-cell receptorVirologyGeneticsGeneIn vitroAcousticsPhysicsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesImmune responses and vaccinations