Bacteriophage-Mediated Perturbation of Defined Bacterial Communities in an <i>In Vitro</i> Model of the Human Gut
Hedieh Attai, Jacob Wilde, Roland Liu, Jessica Chopyk, Andrew G. Garcia, Emma Allen‐Vercoe, David T. Pride
Abstract
, when intersubject perturbations were performed, compared to intrasubject perturbations. These changes were observed when perturbations were performed using live phages, but not when heat-killed phages were used, and they support the use of chemostat systems for studying complex human bacteria-phage dynamics.
Topics & Concepts
BacteriophageMicrobiomeBiologyHuman microbiomeBacteriaIn vitroMicrobiologyComputational biologyGeneticsEscherichia coliGeneBacteriophages and microbial interactionsGut microbiota and healthEvolution and Genetic Dynamics