TFAA/DMSO‐Promoted Fluorination of P(O)−H and P(O)−OH Compounds: Compatible Access to Fluorophosphonates and Phosphonofluoridates
Qiwei Li, Xinyue Zhang, Lu Lu, Zi‐Qian Wu, Li Ji, Guizhi Li, Kai Sun, Shang‐Dong Yang, Bin Yang
Abstract
Abstract A TFAA/DMSO/NaF‐based system for the efficient fluorination of P(O)−H and P(O)−OH compounds has been developed. Without adding highly toxic and expensive fluorination reagents, this novel transformation provides direct and compatible access to a variety of fluorophosphonates and phosphonofluoridates in a one‐pot manner. magnified image
Topics & Concepts
ChemistryReagentCombinatorial chemistryTransformation (genetics)HalogenationMedicinal chemistryOrganic chemistryBiochemistryGeneFluorine in Organic ChemistryOrganophosphorus compounds synthesisSulfur-Based Synthesis Techniques