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Macromolecular Crowding Induces a Binding Competent Transient Structure in Intrinsically Disordered Gab1

Tobias Gruber, Marc Lewitzky, Lisa Machner, Ulrich Weininger, Stephan M. Feller, Jochen Balbach

2021Journal of Molecular Biology21 citationsDOI

Topics & Concepts

Intrinsically disordered proteinsMacromolecular crowdingPhosphorylationProtein tyrosine phosphataseBiophysicsChemistryTyrosineSH2 domainProtein foldingPlasma protein bindingBiochemistryMacromoleculeBiologyProtein Tyrosine PhosphatasesProtein Structure and DynamicsEndoplasmic Reticulum Stress and Disease
Macromolecular Crowding Induces a Binding Competent Transient Structure in Intrinsically Disordered Gab1 | Litcius