Chemo-enzymatic synthesis of chiral 3-substituted tetrahydroquinolines by a sequential biocatalytic cascade and Buchwald–Hartwig cyclization
Zefei Xu, Jinhui Feng, Peiyuan Yao, Qiaqing Wu, Dunming Zhu
Abstract
A one-pot bienzymatic cascade was developed to synthesize ( S )- N -(3-aryl-2-methylpropyl) prop-2-en-1-amines from α,β-unsaturated aldehydes, and 3-substituted tetrahydroquinolines were prepared via Buchwald–Hartwig amination and deallylation.
Topics & Concepts
CascadeChemistryAminationArylCombinatorial chemistryOrganic chemistryCascade reactionStereochemistryCatalysisChromatographyAlkylEnzyme Catalysis and ImmobilizationAsymmetric Hydrogenation and CatalysisChemical synthesis and alkaloids