Sparse dictionary learning recovers pleiotropy from human cell fitness screens
Joshua Pan, Jason J. Kwon, Jessica A. Talamas, Ashir A. Borah, Francisca Vázquez, Jesse S. Boehm, Aviad Tsherniak, Marinka Žitnik, James M. McFarland, William C. Hahn
Topics & Concepts
PleiotropyBiologyFitness functionFitness landscapeComputational biologyGeneEffectorGeneticsPhenotypeComputer scienceMachine learningCell biologyPopulationGenetic algorithmSociologyDemographyCell Image Analysis TechniquesEvolution and Genetic DynamicsSingle-cell and spatial transcriptomics