Cancer Therapy by Targeting Thioredoxin Reductase Based on Selenium-Containing Dynamic Covalent Bond
Shuojiong Pan, Jichun Yang, Shaobo Ji, Tianyu Li, Shiqian Gao, Chenxing Sun, Huaping Xu
Abstract
Thioredoxin Reductase (TrxR) plays a pivotal role in defending cells against reactive oxygen species (ROS) and maintaining a reduced intracellular environment. It has been discovered that TrxR is e...
Topics & Concepts
Thioredoxin reductaseCovalent bondSeleniumThioredoxinChemistryCancer therapyMedicineBiochemistryInternal medicineCancerEnzymeOrganic chemistryFree Radicals and AntioxidantsRedox biology and oxidative stressOrganoselenium and organotellurium chemistry