Roles of Eicosanoids in Regulating Inflammation and Neutrophil Migration as an Innate Host Response to Bacterial Infections
Austin E. F. Sheppe, Mariola J. Edelmann
Abstract
was found to enhance inflammasome activation, driving the formation of pore-induced intracellular traps (PITs), thus trapping bacteria from escaping the dying cell. Finally, eicosanoids and IL-1β released from macrophages are implicated in the efferocytosis of neighboring neutrophils. Neutrophils play an essential role in phagocytosing and degrading PITs and associated bacteria to restore homeostasis. This review focuses on the novel functions of host-derived eicosanoids in the host-pathogen interactions.
Topics & Concepts
BiologyInnate immune systemEicosanoidCell biologySecretionInflammasomeLeukotriene B4MicrobiologyInflammationIntracellularChemotaxisLipid signalingProinflammatory cytokineImmune systemLeukotrieneEicosanoid metabolismArachidonic acidImmunologyEnzymeBiochemistryReceptorAsthmaImmune Response and InflammationNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer