Monofunctional platinum(<scp>ii</scp>) anticancer complexes based on multidentate phenanthridine-containing ligand frameworks
Issiah B. Lozada, Bin Huang, Morgan Stilgenbauer, Travis Beach, Zihan Qiu, Yao‐Rong Zheng, David E. Herbert
Abstract
Phenanthriplatin is a leading preclinical anticancer Pt complex distinguished by a phenanthridine ligand that facilitates DNA-targeted covalent binding via intercalation. We report here that Pt(ii) complexes incorporating phenanthridine into a chelating, multidentate ligand scaffold exhibit a superior in vitro therapeutic index compared with phenanthriplatin and cisplatin.
Topics & Concepts
PhenanthridineDenticityPlatinumChemistryLigand (biochemistry)Combinatorial chemistryStereochemistryMedicinal chemistryReceptorOrganic chemistryBiochemistryMetalCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsMagnetism in coordination complexes