Sesquiterpenoids with neuroprotective activities from the Chloranthaceae plant Chloranthus henryi
Fang-You Chen, Wanwan Yu, Feng-Xiang Lin, Ji‐Wu Huang, Wei-Ming Huang, Peng-Cheng Shuang, Yuting Bian, Yong‐Ming Luo
Abstract
A rare sesquiterpenoid possessing a 6/6 bicyclic system fused with two clustered furan units and a pair of guaiane-type sesquiterpenoids were acquired from the roots of Chloranthus henryi. Their structures with absolute configurations were characterized with spectroscopic data, ECD, and X-ray diffraction analysis. All three sesquiterpenoids showed moderate neuroprotective activities on PC12 cells damaged with hydrogen peroxide.
Topics & Concepts
NeuroprotectionHydrogen peroxideStereochemistryBotanyAbsolute configurationChemistryBiologyOrganic chemistryPharmacologySesquiterpenes and Asteraceae StudiesNatural product bioactivities and synthesisPhytochemistry and Biological Activities