Replacement of the native cis prolines by alanine leads to simplification of the complex folding mechanism of a small globular protein
Anushka Kaushik, Jayant B. Udgaonkar
Topics & Concepts
IsomerizationChemistryFolding (DSP implementation)Native statePeptide bondProtein foldingStereochemistryFolding funnelAlanineGlobular proteinPeptideCrystallographyPhi value analysisDownhill foldingBiophysicsAmino acidBiochemistryCatalysisBiologyEngineeringElectrical engineeringProtein Structure and DynamicsEnzyme Structure and FunctionBiochemical and Structural Characterization