Inhibition of Th1 activation and differentiation by dietary guar gum ameliorates experimental autoimmune encephalomyelitis
Naomi M. Fettig, Hannah G Robinson, Jessica R. Allanach, Katherine M. Davis, Rachel L. Simister, Elsie J. Wang, Andrew J Sharon, Jiayu Ye, Sarah Popple, Jung Hee Seo, Deanna L. Gibson, Sean A. Crowe, Marc S. Horwitz, Lisa C. Osborne
Abstract
T cells of guar gum-supplemented mice are less encephalitogenic due to reduced activation, proliferation, Th1 differentiation, and altered migratory potential. These findings reveal specificity in the host response to fiber sources and define a pathway of fiber-induced immunomodulation that protects against pathologic neuroinflammation.
Topics & Concepts
Experimental autoimmune encephalomyelitisGuar gumImmune systemMultiple sclerosisNeuroinflammationAutoimmune diseaseImmunologyEncephalomyelitisInflammationBiologyChemistryBiochemistryAntibodyProbiotics and Fermented FoodsPolysaccharides and Plant Cell WallsImmune Response and Inflammation