Photoredox-Catalyzed α-Aminoalkylcarboxylation of Allenes with CO<sub>2</sub>
Hyungwoo Hahm, Doohyun Baek, Dowon Kim, Seong-Wook Park, Jeong Yup Ryoo, Sukwon Hong
Abstract
-dimethylanilines is reported for the first time (26 examples, up to 96% yield). In the case of electron-deficient allenes, good regioselectivity was observed (up to 94:6), exclusively generating kinetic products over thermodynamic products. This protocol is a novel synthetic method for highly functionalized β,γ-unsaturated γ-aminobutyric esters.
Topics & Concepts
ChemistryRegioselectivityYield (engineering)CatalysisArylPhotoredox catalysisCombinatorial chemistryOrganic chemistryPhotocatalysisAlkylMetallurgyMaterials scienceCarbon dioxide utilization in catalysisCatalytic C–H Functionalization MethodsCO2 Reduction Techniques and Catalysts