High-throughput characterization of functional variants highlights heterogeneity and polygenicity underlying lung cancer susceptibility
Erping Long, Harsh Patel, Alyxandra Golden, Michelle Antony, Jinhu Yin, Karen Funderburk, James Feng, Lei Song, Jason W. Hoskins, Laufey T. Ámundadóttir, Rayjean J. Hung, Christopher I. Amos, Jianxin Shi, Nathaniel Rothman, Qing Lan, Jiyeon Choi
Topics & Concepts
BiologyGenome-wide association studyGeneticsLinkage disequilibriumEpigenomicsGenetic associationFunctional genomicsComputational biologyLocus (genetics)GeneAlleleHaplotypeSingle-nucleotide polymorphismGenomeGenomicsDNA methylationGenotypeGene expressionEpigenetics and DNA MethylationRNA modifications and cancerCancer-related molecular mechanisms research