Visible‐Light‐Induced Radical Cascade Cyclization of <i>o‐</i>Diisocyanoarenes: Synthesis of Diethyl Benzo[<i>a</i>]phenazine‐6,6(5<i>H</i>)‐Dicarboxylate
Yao Yuan, Si‐Yuan Zhang, Wuheng Dong, Feng Wu, Xiaomin Xie, Zhaoguo Zhang
Abstract
Abstract A visible‐light‐induced radical cascade cyclization of ortho ‐diisocyanoarenes for the synthesis of diethyl benzo[ a ]phenazine‐6,6(5 H )‐dicarboxylates has been developed. This process provides an efficient and convenient protocol for the construction of benzo[ a ]phenazine skeleton that widely present in biologically active molecules and pharmaceuticals. The reaction takes place under mild conditions and the products are obtained in moderate to excellent yields. magnified image
Topics & Concepts
PhenazineChemistryCascadeRadical cyclizationMoleculeStereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryChromatographyRadical Photochemical ReactionsSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods