Pd-catalysed hydrodehalogenation of aryl chlorides: a mild method for deuteration and detoxification
Angela Burhenn, Roberta Bavaro, Viktoria H. Gessner
Abstract
The hydrodehalogenation of haloarenes at room temperature using ethanol as hydride source and a Pd-catalyst with an ylide-substituted phosphine is reported. The protocol can be used for deuterations and detoxifications of chlorinated biphenyls.
Topics & Concepts
PhosphineCatalysisChemistryArylYlideEthanolDetoxification (alternative medicine)Organic chemistryHydrideCombinatorial chemistryAlkylHydrogenPathologyMedicineAlternative medicineChemical Reactions and IsotopesCatalytic Cross-Coupling ReactionsAsymmetric Hydrogenation and Catalysis