RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
Jingya Qin, Lulu Xue, Ningqiang Gong, Hanwen Zhang, Sarah J. Shepherd, Rebecca M. Haley, Kelsey L. Swingle, Michael J. Mitchell
Abstract
, 1A RGD-based hybrid LNPs showed comparable mRNA delivery to the liver and spleen, when compared to a non-targeted control, and had increased expression in the whole body. Overall, this RGD-based hybrid LNP system is a promising platform for targeted mRNA delivery, which may allow for mRNA-based protein replacement and gene editing in a more efficient and specific manner with reduced off-target effects.
Topics & Concepts
Messenger RNAGene deliveryTransfectionChemistryIn vitroIn vivoMolecular biologyCell biologyGeneBiologyBiochemistryGeneticsRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesVirus-based gene therapy research