Targeting Apollo-NADP <sup>+</sup> to Image NADPH Generation in Pancreatic Beta-Cell Organelles
Huntley H. Chang, Alex M. Bennett, D. William Cameron, Eric Floro, Aaron Au, Christopher McFaul, Christopher M. Yip, Jonathan V. Rocheleau
Abstract
sensors to reveal the prominent role of beta-cell mitochondria in determining NADPH production in the cytoplasm, nucleus, and peroxisome.
Topics & Concepts
OrganelleCytoplasmMitochondrionPeroxisomeCellCell biologyNucleusBiochemistryBiologyChemistryGenePancreatic function and diabetesCalcium signaling and nucleotide metabolismAdvanced biosensing and bioanalysis techniques