Insights into durability against resistance from the antibiotic nitrofurantoin
Riannah Kettlewell, Charlotte Jones, Timothy Felton, Mato Lagator, Danna R. Gifford
Abstract
Nitrofurantoin has shown exceptional durability against resistance over 70 years of use. This longevity stems from factors such as rapid achievement of therapeutic concentrations, multiple physiological targets against bacteria, low risk of horizontal gene transfer, and the need to acquire multiple mutations to achieve resistance. These combined features limit resistance emergence and spread of nitrofurantoin resistance. We propose nitrofurantoin as an exemplar for developing other durable treatments.
Topics & Concepts
NitrofurantoinDurabilityAntibiotic resistanceResistance (ecology)AntibioticsBiologyBiotechnologyMicrobiologyMaterials scienceEcologyComposite materialUrinary Tract Infections ManagementAntibiotic Resistance in BacteriaAntibiotic Use and Resistance