The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report
Erin Yamamoto, Jacob H. Bagley, Mathew Geltzeiler, Olabisi Sanusi, Aclan Dog⫧an, Jesse Liu, Juan Piantino
Abstract
The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.
Topics & Concepts
Glymphatic systemPerivascular spaceCerebrospinal fluidParenchymaInterstitial fluidPathologyInterstitial spaceMedicineNeuroscienceBiologyCerebrospinal fluid and hydrocephalusFetal and Pediatric Neurological DisordersSpinal Dysraphism and Malformations