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Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors

Ehab M. Gedawy, Asmaa E. Kassab, Ahmed M. El Kerdawy

2020European Journal of Medicinal Chemistry83 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCelecoxibPharmacologyPyrazoleAnalgesicSulfonamideAnti-inflammatoryProdrugIC50StereochemistryBiochemistryIn vitroMedicineInflammatory mediators and NSAID effectsSynthesis and Biological EvaluationSynthesis of β-Lactam Compounds
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors | Litcius