Installing the “magic methyl” – C–H methylation in synthesis
Daniya Aynetdinova, Mia Callens, Harry B. Hicks, Charmaine Y. X. Poh, Benjamin D. A. Shennan, Alistair M. Boyd, Zhong Hui Lim, Jamie A. Leitch, Darren J. Dixon
Abstract
carbon centres has become a powerful transformation in the synthetic toolbox. Due to the potential for profound changes to physicochemical properties attributed to the installation of a "Magic Methyl" group at a strategic site in a lead compound, such techniques have become highly desirable in modern drug discovery and synthesis programmes. This review will cover the diverse techniques that have been employed to enable the selective installation of the C-Me bond in a wide range of chemical structures, from simple building blocks to complex drug-like architectures.
Topics & Concepts
MethylationMAGIC (telescope)InstallationPotencyChemistryCombinatorial chemistryComputer scienceOperating systemBiochemistryPhysicsIn vitroDNAQuantum mechanicsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions