c-Myc overexpression increases ribosome biogenesis and protein synthesis independent of mTORC1 activation in mouse skeletal muscle
Takahiro Mori, Satoru Ato, Jonas R. Knudsen, Carlos Henríquez‐Olguín, Zhencheng Li, Koki Wakabayashi, Takeshi Suginohara, Kazuhiko Higashida, Yuki Tamura, Koichi Nakazato, Thomas E. Jensen, Riki Ogasawara
Abstract
Resistance exercise is known to increase c-Myc expression, which is known to stimulate ribosome biogenesis and protein synthesis in a variety of cells. However, whether the increase in c-Myc stimulates ribosome biogenesis and protein synthesis in skeletal muscles remains unknown. We found that c-Myc overexpression is sufficient to stimulate skeletal muscle ribosome biogenesis and protein synthesis without activation of mTORC1.
Topics & Concepts
mTORC1Ribosome biogenesisSkeletal muscleCell biologyRibosomeBiogenesisProtein biosynthesisChemistryBiologyGeneEndocrinologyBiochemistrySignal transductionRNAPI3K/AKT/mTOR pathwayMuscle Physiology and DisordersPI3K/AKT/mTOR signaling in cancerUbiquitin and proteasome pathways