Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity — Introducing High NET Affinity PET Probe <sup>18</sup>F-AF78
Xinyu Chen, Rudolf A. Werner, Kazuhiro Koshino, Naoko Nose, Saskia Mühlig, Steven P. Rowe, Martin G. Pomper, Constantin Lapa, Michael Decker, Takahiro Higuchi
Abstract
F-AF78 is an SNS imaging agent with strong potential to guide specific interventions in cardiovascular medicine.
Topics & Concepts
In vivoNorepinephrine transporterDesipramineChemistryNorepinephrineIn vitroBiomarkerCatecholamineKineticsSympathetic nervous systemPharmacologyBiophysicsTransporterInternal medicineBiologyMedicineBiochemistryDopamineGeneBlood pressurePhysicsHippocampusAntidepressantBiotechnologyQuantum mechanicsCardiac electrophysiology and arrhythmiasCardiac Imaging and DiagnosticsIon channel regulation and function