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Machine Learning‐Guided Discovery of High‐Entropy Perovskite Oxide Electrocatalysts via Oxygen Vacancy Engineering

Panesun Tukur, Yong Wei, Yinning Zhang, Hanning Chen, Yuewei Lin, Selena He, Yirong Mo, Jianjun Wei

2025Small18 citationsDOIOpen Access PDF

Abstract

High-entropy perovskite oxides (HEPOs) have recently emerged as multifunctional catalysts. However, the HEPOs' structural and compositional complexity hinders the easy and accurate extrapolation of activity indicators, which are essential for establishing structure-property correlations. Here, OxiGraphX, is introduced as a novel graph neural network (GNN) model designed to capture the complex relationships among structure, composition, and atomic chemical environments for accurate prediction of oxygen vacancy formation energies (OVFEs) in HEPOs. By integrating machine learning (ML), density functional theory (DFT), and experimental validation, this work demonstrates an efficient framework for rapidly and accurately screening HEPO electrocatalysts for oxygen evolution reaction (OER). The OxiGraphX predicts OVFEs with a precision exceeding existing data, enabling the identification of compositions of higher oxygen vacancy content (OVC) and, thus, higher catalytic activity. Furthermore, the model explores latent spaces that translate effectively into experimental domains, bridging computational predictions with real-world applications. This approach accelerates the discovery of high-performance HEPO catalysts while providing deeper insights into their catalytic mechanisms.

Topics & Concepts

CatalysisExtrapolationDensity functional theoryOxygenMaterials sciencePerovskite (structure)Vacancy defectBiological systemComputer scienceChemical physicsChemistryComputational chemistryCrystallographyBiologyMathematicsOrganic chemistryMathematical analysisBiochemistryElectrocatalysts for Energy ConversionMachine Learning in Materials ScienceAdvanced Photocatalysis Techniques