Evidence for “cocktail”-type catalysis in Buchwald–Hartwig reaction. A mechanistic study
Darya O. Prima, Malena Madiyeva, Julia V. Burykina, Mikhail E. Minyaev, Daniil A. Boiko, Valentine P. Ananikov
Abstract
The mechanism of the C–N cross-coupling reaction, catalyzed by Pd/NHC, was evaluated at the molecular and nanoscale levels. The first evidence for the involvement of a “cocktail”-type system in the Buchwald–Hartwig reaction is provided.
Topics & Concepts
CatalysisCoupling reactionCombinatorial chemistryChemistryReaction mechanismMechanism (biology)Reaction conditionsStereochemistryOrganic chemistryPhysicsQuantum mechanicsCatalytic Cross-Coupling ReactionsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryChemical Synthesis and Analysis