2,3-Dihydro-1,3,4-thiadiazoles as dual B-Raf / VEGFR-2 inhibitors: Design, synthesis, and anti-breast cancer assessment
Walid E. Elgammal, Hazem Elkady, Hazem A. Mahdy, Alaa Elwan, Dalal Z. Husein, Fatma G. Amin, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa, Ahmed M. Metwaly
Topics & Concepts
ChemistryBreast cancerCancerApoptosisCancer researchIn vitroCancer cellLead compoundCell cycle checkpointPharmacologyCytotoxic T cellKinaseHuman breastStructure–activity relationshipCytotoxicityPharmacokineticsSmall moleculeDual (grammatical number)Cancer cell linesCell cultureCell growthBiological activityInhibitory postsynaptic potentialCellCell cycleIC50Synthesis and biological activityAngiogenesis and VEGF in CancerMelanoma and MAPK Pathways