Tandem sequential catalytic enantioselective synthesis of highly-functionalised tetrahydroindolizine derivatives
Shuyue Zhang, Mark D. Greenhalgh, Alexandra M. Z. Slawin, Andrew D. Smith
Abstract
ring-opening and cyclisation, led to a range of 24 tetrahydroindolizine derivatives containing three stereocentres in up to >95 : 5 dr and >99 : 1 er.
Topics & Concepts
Enantioselective synthesisTandemCombinatorial chemistryCatalysisChemistryOrganic chemistryMaterials scienceComposite materialCyclopropane Reaction MechanismsSynthesis and Reactivity of HeterocyclesSynthesis and Characterization of Pyrroles