MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy
Enrica Chiti, Marco Di Paolo, Emanuela Turillazzi, Anna Rocchi
Abstract
MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length, involved in the regulation of many biochemical pathways in the human body. The level of miRNAs in tissues and circulation can be deregulated because of altered pathophysiological mechanisms; thus, they can be employed as biomarkers for different pathological conditions, such as cardiac diseases. This review summarizes published findings of these molecular biomarkers in the three most common structural cardiomyopathies: human dilated, arrhythmogenic and hypertrophic cardiomyopathy.
Topics & Concepts
microRNAPathologicalDilated cardiomyopathyHypertrophic cardiomyopathyCardiomyopathyMedicinePathophysiologyBioinformaticsBiologyInternal medicineHeart failureGeneticsGeneCardiovascular Effects of ExerciseCardiomyopathy and Myosin StudiesViral Infections and Immunology Research