Short-chain fatty acids play a positive role in colorectal cancer
Gang Liu, Jingtong Tang, Jianping Zhou, Ming Dong
Abstract
Short-chain fatty acids (SCFAs) are produced by bacterial fermentation in the colon and are thought to be protective against gastrointestinal disease. SCFAs such as acetate, propionate and butyrate are important metabolites in the maintenance of intestinal homeostasis and have been shown to be beneficial in colorectal cancer (CRC). SCFAs are responsible for maintaining a normal intestinal barrier and exhibit numerous immunomodulatory functions. In this review article, we will discuss the metabolism and mechanism of action of SCFAs and their effects on the CRC, with particular emphasis on dietary fiber treatment and the clinical research progress.
Topics & Concepts
ButyratePropionateColorectal cancerMechanism (biology)HomeostasisCancerShort-chain fatty acidBiochemistryMedicineCancer researchChemistryInternal medicineFermentationEpistemologyPhilosophyGut microbiota and healthDiet and metabolism studiesCancer, Stress, Anesthesia, and Immune Response