Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity
Fatma A. Mohamed, Hesham A. M. Gomaa, Omnia M. Hendawy, Asmaa T. Ali, Hatem S. Farghaly, Ahmed M. Gouda, Ahmed H. Abdelazeem, Mostafa Abdelrahman, Laurent Trembleau, Bahaa G. M. Youssif
Topics & Concepts
ChemistryHydroxymethylEGFR inhibitorsDocking (animal)ErlotinibIndole testApoptosisCarboxamideStereochemistryCell cycle checkpointCaspase 3CytotoxicityCell culturePharmacologyCell cycleBiochemistryEpidermal growth factor receptorIn vitroProgrammed cell deathReceptorMedicineGeneticsBiologyNursingCancer therapeutics and mechanismsComputational Drug Discovery MethodsSynthesis and biological activity