Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border
Makoto Saito, Widi Yotyingaphiram, Zillah Cargill, Mary Ellen Gilder, Aung Myat Min, Aung Pyae Phyo, Thi Dar San, Hilda Poe, Cindy S. Chu, Nicholas J. White, François Nosten, Rose McGready
Abstract
= 0.91). QTc prolongation resulted mainly from widening of the JT interval. In pregnant women, none of the antimalarial drug treatments exceeded conventional thresholds for an increased risk of torsade de pointes.
Topics & Concepts
MalariaChloroquineMedicineQT intervalRandomized controlled trialProtozoal diseaseDrugElectrocardiographyMefloquinePharmacologyInternal medicineImmunologyEpilepsy research and treatmentMalaria Research and ControlCardiac electrophysiology and arrhythmias