KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition
Liberalis Debraj Boila, Subhadeep Ghosh, Subham K. Bandyopadhyay, Liqing Jin, Alex Murison, Andy G.X. Zeng, Wasim Shaikh, Satyaki Bhowmik, Siva Sai Naga Anurag Muddineni, Mayukh Biswas, Sayantani Sinha, Shankha Subhra Chatterjee, Nathan Mbong, Olga I. Gan, Anwesha Bose, Sayan Chakraborty, Andrea Arruda, James A. Kennedy, Amanda Mitchell, Eric R. Lechman, Debasis Banerjee, Michael Milyavsky, Mark D. Minden, John E. Dick, Amitava Sengupta
Topics & Concepts
Synthetic lethalityCancer researchMyeloid leukemiaDNA repairPoly ADP ribose polymeraseBiologyNPM1LeukemiaDNA damageHistoneEpigeneticsDaunorubicinGeneImmunologyGeneticsDNAPolymeraseKaryotypeChromosomeAcute Myeloid Leukemia ResearchPARP inhibition in cancer therapyHistone Deacetylase Inhibitors Research