Solid-state emitting twisted π-conjugate as AIE-active DSE-gen:<i>in vitro</i>anticancer properties against FaDu and 4T1 with biocompatibility and bioimaging
Shouvik Bhuin, Pravesh Sharma, Purbali Chakraborty, Onkar P. Kulkarni, Manab Chakravarty
Abstract
anticancer probe. Thus, we present a potentially applicable anticancer drug, offering a bioactive material with bioimaging efficacy and a way to detect dead cancer cells selectively. The primary mechanism behind the identified outcomes is deciphered with the support of experimental (steady-state and time-resolved fluorescence, biological assays, cellular uptake) and molecular docking studies.
Topics & Concepts
ConjugateHEK 293 cellsBiocompatibilityFluorescenceIn vitroSolid-stateMaterials scienceNanotechnologyBiophysicsChemistryBiochemistryBiologyPhysicsPhysical chemistryQuantum mechanicsMetallurgyGeneMathematicsMathematical analysisLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniquesClick Chemistry and Applications