Association of <i>FTO</i> rs9939609 polymorphism with serum leptin, insulin, adiponectin, and lipid profile in overweight adults
Mahsa Mehrdad, Saeid Doaei, Maryam Gholamalizadeh, Majid Fardaei, Mohammad Fararouei, Mohammad Eftekhari
Abstract
rs9939609 risk allele (A) had higher serum leptin (p = 0.005, F: 5.131) and lower HDL (p = 0.001, F: 7.687) level than TT genotype. The differences between TT and AT genotypes were not significant. The association remained significant for HDL level after adjustments for age and sex, calorie intake, physical activity, and BMI. The association between rs9939609 polymorphism genotypes and leptin was disappeared after adjustments for calorie intake and physical activity. In conclusion, rs9939609 risk allele was associated with higher serum leptin and lower HDL levels in overweight people. Further studies are warranted.
Topics & Concepts
Internal medicineEndocrinologyLeptinOverweightAdiponectinObesityFTO geneMedicineBody mass indexInsulinGenotypeLipid profileCholesterolPolymorphism (computer science)BiologyInsulin resistanceGeneGeneticsGenetic Associations and EpidemiologyNutrition, Genetics, and DiseaseAdipokines, Inflammation, and Metabolic Diseases