Albumin-Energized NIR-II Cyanine Dye for Fluorescence/Photoacoustic/Photothermal Multi-Modality Imaging-Guided Tumor Homologous Targeting Photothermal Therapy
Shanshan Jiang, Wanyu Li, Benhao Li, Shuai Chen, Lei Shan, Yurong Liu, Jing Lin, Peng Huang
Abstract
Endowing cyanine dyes with hydrophilicity, long blood circulation, tumor targeting, and robust therapeutic efficacy in the second near-infrared (NIR-II) window is challenging for cancer treatment. Herein, we develop cancer cell membrane-coated albumin-NIR-II cyanine dye assemblies, denoted as LZ-1105@HAm, to optimize the photophysical properties of cyanine dyes in aqueous solution for NIR-II fluorescence (FL)/photoacoustic (PA)/photothermal (PT) multimodality imaging-guided tumor homologous targeting photothermal therapy. LZ-1105@HAm exhibits good hydrophilicity, extends the half-life of blood circulation from 0.634 ± 0.058 to 1.919 ± 0.107 h, enhances NIR-II FL/PA/PT imaging capabilities in vitro and in vivo, and improves photothermal conversion efficiency from 34.6% to 45.4%. Additionally, the cell membrane coating confers the assemblies with tumor-specific targeting capability, increasing tumor accumulation and enabling efficient photothermal tumor ablation. Upon 1064 nm laser irradiation, LZ-1105@HAm demonstrates significantly improved therapeutic efficacy. This research provides a strategy for constructing cyanine dye-based nanotheranostics with potential clinical application prospects.