Notch1 switches progenitor competence in inducing medulloblastoma
Claudio Ballabio, Matteo Gianesello, Chiara Lago, Konstantin Okonechnikov, Marica Anderle, Giuseppe Aiello, Francesco Antonica, Tingting Zhang, Francesca Gianno, Felice Giangaspero, Bassem A. Hassan, Stefan M. Pfister, Luca Tiberi
Abstract
expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation.
Topics & Concepts
MedulloblastomaProgenitorProgenitor cellCompetence (human resources)NeuroscienceCancer researchBiologyComputer scienceCell biologyStem cellPsychologySocial psychologyDevelopmental Biology and Gene RegulationEpigenetics and DNA MethylationHedgehog Signaling Pathway Studies