Tissue factor cytoplasmic domain exacerbates post-infarct left ventricular remodeling via orchestrating cardiac inflammation and angiogenesis
Suet Yen Chong, Olga Zharkova, Siti Maryam J. M. Yatim, Xiaoyuan Wang, Xiong Chang Lim, Chenyuan Huang, Chia Yee Tan, Jianming Jiang, Lei Ye, Michelle Siying Tan, Véronique Angeli, Henri H. Versteeg, Mieke Dewerchin, Peter Carmeliet, Carolyn S.P. Lam, Mark Y. Chan, Dominique P.V. de Kleijn, Jiong‐Wei Wang
Abstract
Our findings demonstrate that the TF cytoplasmic domain exacerbates post-infarct cardiac injury and adverse LV remodeling via differential regulation of inflammation and angiogenesis. Targeted inhibition of the TF cytoplasmic domain-mediated intracellular signaling may ameliorate post-infarct LV remodeling without perturbing coagulation.
Topics & Concepts
Tissue factorInflammationMedicineMyocardial infarctionVentricular remodelingProinflammatory cytokineEjection fractionAngiogenesisCD68CTGFPathologyInternal medicineCardiologyHeart failureImmunohistochemistryReceptorGrowth factorCoagulationCardiac Fibrosis and RemodelingSignaling Pathways in DiseaseCardiac Structural Anomalies and Repair