Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing <i>Yersinia pseudotuberculosis</i>
Shreya Das, Mohd Saqib, Ryan Meng, Sridar V. Chittur, Ziqiang Guan, Fengyi Wan, Wei Sun
Abstract
Significance Our study highlights that hemochromatotic hosts are susceptible to the siderophilic enteropathogenic Yersinia because of dysregulated interleukn (IL)-1β signaling that causes rapid disruption of the intestinal tight junction, leading to acute systemic infection. This study also poses early intervention of anti–IL-1β therapy as a potentially novel strategy for treating hemochromatotic patients with severe siderophilic bacterial infections.
Topics & Concepts
Yersinia pseudotuberculosisBiologyImmunologySignal transductionMyosin light-chain kinaseCytokineNeutrophiliaChemokineMicrobiologyComplement systemImmune systemCell biologyVirulencePhosphorylationGeneticsGeneYersinia bacterium, plague, ectoparasites researchPlant-based Medicinal ResearchPharmacological Effects of Natural Compounds