Multiphysics Analysis of Reversible Electroporation and Electrodeformation of Cervical Cells Using a Nanosecond Pulse Generator
Mayank Kumar, Ashutosh Mishra
Abstract
We present an agglomerative in-silico study that explores the feasibility of leveraging nanosecond pulsed electric field on cervical cell samples toward improving cervical cell neoplasia and cancer detection by enhancing the visual fidelity of the screening tests. This comprehensive, multimodal study explores the effect of these pulsed electric fields on membrane electroporation and deformation in cell clusters extracted from real cervical sample images. Apart from performing a quantitative assessment of dye uptake change under the predefined electric stress, we also perform a thermal analysis to check whether the thermal envelope is breached during the application of a pulsed electric field. For the sake of completeness, we also present the hardware details of a Marx generator-based pulsar that provides the necessary stimulus for various multiphysics studies.