Plant green pigment of chlorophyllin attenuates inflammatory bowel diseases by suppressing autophagy activation in mice
Tianci Zhang, Ruofei Zhang, Guangfu Zhao, Wei Liu, Liwei Pan, Ying Tong, Mingshan Jiang, Hu Zhang, Zhi‐Xiong Jim Xiao, Stephen J. Pandol, Xiansheng Fu, Yuan‐Ping Han, Xiaofeng Zheng
2022American Journal of Physiology-Gastrointestinal and Liver Physiology12 citationsDOIOpen Access PDF
Abstract
Inflammatory bowel disease (IBD) is a chronic and recurrent gastrointestinal disease, while the etiology remains poorly understood. Dietary composition and lifestyle are crucial for pathogenesis and progression of IBD. In this study, we observed that autophagy in the intestinal tissue was persistently activated in IBD mice. Chlorophyllin (CHL), a water-soluble derivate of chlorophyll, can attenuate colitis by regulating autophagy and inflammation. Thus, consumption of green vegetables and chlorophyllin may be beneficial for IBD recovery.
Topics & Concepts
AutophagyChlorophyllinInflammatory bowel diseasePathogenesisInflammationColitisMedicineDiseaseImmunologyCancer researchBiologyChlorophyllInternal medicineBiochemistryBotanyApoptosisAutophagy in Disease and TherapyGenomics, phytochemicals, and oxidative stressBerberine and alkaloids research